The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia

Autor: Marcos González Díaz, R. G. Sanz, Edwige Voisset, David Grimwade, Christelle Vincent-Fabert, Richard Dillon, Ana Africa Martín López, Jelena V. Jovanovic, M C Chillón, Estelle Duprez, Yvonne G Morgan, Norma C. Gutiérrez, Eskinder Solomon, J. Lok
Přispěvatelé: King‘s College London, Hospital Universitario de Salamanca, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Guy's Hospital [London], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Acute promyelocytic leukemia
Cancer Research
Oncogene Proteins
Fusion
medicine.drug_class
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
Translocation
Genetic
Fusion gene
Retinoids
03 medical and health sciences
Promyelocytic leukemia protein
0302 clinical medicine
Leukemia
Promyelocytic
Acute
medicine
Humans
Retinoid
Progenitor cell
ComputingMilieux_MISCELLANEOUS
Chromosomes
Human
Pair 15
Retinoic Acid Receptor alpha
Stem Cells
Nuclear Proteins
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
Hematology
Hematopoietic Stem Cells
medicine.disease
Virology
3. Good health
DNA-Binding Proteins
Leukemia
Haematopoiesis
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer research
biology.protein
Stem cell
Carrier Proteins
Chromosomes
Human
Pair 17
Transcription Factors
Zdroj: Leukemia
Leukemia, 2017, 31 (3), pp.747-751. ⟨10.1038/leu.2016.338⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2017, 31 (3), pp.747-751. ⟨10.1038/leu.2016.338⟩
ISSN: 0887-6924
1476-5551
Popis: Letter to the Editor.
These data were presented in part at the 56th American Society of Hematology meeting, San Francisco, December 2014.
Databáze: OpenAIRE
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