Effect of a milk diet on rat gastric mucosa: Receptor activity, histamine metabolism and ultrastructural analyses
| Autor: | F. Hervatin, Shahin Emami, F. Chatelet, Eric Chastre, Ch. Gespach, B. Garzon, R. Ducroc |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Receptors Prostaglandin Immunology Receptors Cell Surface Biology Toxicology Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone chemistry.chemical_compound Parietal Cells Gastric Histamine H2 receptor Gastric glands Internal medicine Cyclic AMP Receptors Glucagon medicine Gastric mucosa Animals Pharmacology (medical) Receptors Histamine H1 Cimetidine Enterochromaffin-like cell Parietal cell Pharmacology Rats Inbred Strains Diet Rats Milk medicine.anatomical_structure Endocrinology chemistry Gastric Mucosa Histidine decarboxylase activity Cattle Histamine medicine.drug |
| Zdroj: | Agents and Actions. 20:265-269 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf02074687 |
| Popis: | A bovine milk diet (BM) resulted in remarkable changes in histamine H2 receptor activity (sensitization) and PGE2 receptor activity (desensitization) in gastric glands isolated from adult rats. In contrast, the receptor-cAMP systems sensitive to glucagon(s) and secretin in parietal cells and muco-peptic cells were unaffected. In the two experimental groups, cimetidine produced a parallel displacement of the histamine dose-response curve suggesting competitive inhibition between this classical H2 receptor antagonist and histamine. The BM diet reduced the histidine decarboxylase activity in rat gastric mucosa; the histamine content was not significantly different in control and BM-fed rats. There was no alteration of the circadian rhythm of the parietal cell (ultrastructural changes: microvilli, tubulo-vesicles) determined at intervals of 6 hours in milk-fed rats. Prostaglandins and other components in milk (EGF, somatostatin, etc.) might therefore protect gastric mucosa by a differential control of PGE2 and histamine H2 receptor activity, either directly (PGE2 and EGF in milk) or indirectly (inhibition of endogeneous histamine synthesis/release and stimulation of prostaglandin synthesis/release). |
| Databáze: | OpenAIRE |
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