Targeting CD147 is a Novel Strategy for Antitumor Therapy
| Autor: | Jianglin Zhang, Chengxiang Lian, Xiang Chen, Cong Peng, Yeye Guo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Metalloproteinase Melanoma Cancer Membrane Proteins Antineoplastic Agents Matrix metalloproteinase Biology medicine.disease Metastasis Extracellular matrix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Neoplasms Drug Discovery Cancer research medicine Immunoglobulin superfamily Humans Molecular Targeted Therapy Lung cancer Cell Proliferation |
| Zdroj: | Current pharmaceutical design. 23(29) |
| ISSN: | 1873-4286 |
| Popis: | CD147 is a membrane protein belonging to immunoglobulin superfamily and expressed in the cell membrane, which is also named with an extracellular matrix metalloproteinase inducer (EMMPRIN) because this molecule induces adjacent fibroblasts or tumor cells to produce MMPs, facilitating tumor cells migration and invasion. Accumulating evidences have shown that CD147 is over-expressed in various tumors, including melanoma, liver cancer, and lung cancer, and orchestrates tumor cell proliferation, apoptosis, invasion and metastasis, multidrug resistance and glycolysis through critical molecules such as MMPs, MCTs, Caveolin-1, and VEGF. In this review, we focus on understanding the characteristics of CD147 in various biological functions, including physiological and pathological processes. Recent novel studies have shown that CD147 is not only a potential diagnostic marker but also a therapeutic target for chemotherapy or the diagnosis of cancer. |
| Databáze: | OpenAIRE |
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