Tests for determining in-use concentrations of antibiotics and disinfectants are based on entirely different concepts: 'Resistance' has different meanings

Autor: O. Cerf, B. Carpentier, Pascal Sanders
Přispěvatelé: Alfort veterinary school, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Unité de Toxicologie des Contaminants, Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)
Rok vydání: 2010
Předmět:
medicine.drug_class
Disinfectant
Resistance
Antibiotics
MESH: Consumer Product Safety
Microbial Sensitivity Tests
Drug resistance
Biology
Microbiology
MESH: Dose-Response Relationship
Drug
03 medical and health sciences
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication
antibioresistance
MESH: Anti-Bacterial Agents
Drug Resistance
Bacterial
MESH: Drug Resistance
Bacterial
medicine
Humans
Meaning (existential)
Positive economics
MESH: Food Microbiology
Minimum inhibitory concentration (MIC)
030304 developmental biology
MESH: Microbial Sensitivity Tests
0303 health sciences
MESH: Humans
Bacteria
Dose-Response Relationship
Drug
Resistance (ecology)
030306 microbiology
business.industry
MESH: Disinfectants
Antibiotic
General Medicine
Anti-Bacterial Agents
3. Good health
Biotechnology
MESH: Bacteria
Consumer Product Safety
Food Microbiology
Minimum bactericidal concentration (MBC)
Therapeutic failure
business
Tolerance
Disinfectants
Food Science
Zdroj: International Journal of Food Microbiology
International Journal of Food Microbiology, Elsevier, 2010, 136 (3), pp.247-54. ⟨10.1016/j.ijfoodmicro.2009.10.002⟩
ISSN: 0168-1605
DOI: 10.1016/j.ijfoodmicro.2009.10.002
Popis: There are concerns that more extensive application of disinfectants in the food industry could result in increased resistance of bacteria to antibiotics and that therapeutic failure could ensue. This paper highlights the differences in application and mode of action between antibiotics in human or animal medicine and disinfectants in the food industry. It describes the completely different methods used to determine in-use concentrations in the two contexts. It points out that the minimum inhibitory concentration (MIC) is never the concentration at which disinfectants should be applied. It also discusses erroneous conclusions that may be drawn when the failure of therapy or disinfection is attributed to intrinsic properties of the molecules rather than to misuse of antibiotics or disinfectants. The paper suggests that the intended meaning of the word "resistance" be carefully defined in scientific articles with due reference to the measurement mentioned in the abstract and possibly reflected in the title. It also suggests that in matters of disinfection the word "resistance" be preferred when the phenomenon being studied is killing and "tolerance" when it is the adaptation to inhibitory concentrations.
Databáze: OpenAIRE
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