Molecular Genetic Analysis of HLA-DR and -DQ Alleles in Spanish Patients with Melanoma
| Autor: | M. D. Planelles, E. Ledesma, Eduardo Nagore, Amelia Insa, V. Oliver, J. M. Millan, José M. Fortea, Carlos Guillén |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Skin Neoplasms Adolescent endocrine system diseases Population Dermatology Human leukocyte antigen Gene Frequency HLA-DQ Antigens medicine HLA-DR Humans Genetic Predisposition to Disease Allele education Melanoma Allele frequency Aged education.field_of_study Polymorphism Genetic HLA-DQ Antigen business.industry Cancer HLA-DR Antigens General Medicine Middle Aged medicine.disease Spain Immunology business |
| Zdroj: | ACTA DERMATO-VENEREOLOGICA r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 0001-5555 |
| DOI: | 10.1080/00015550252948095 |
| Popis: | Controversial data have been reported about HLA alleles and susceptibility to melanoma. The relationship between distribution of HLA alleles in patients with melanoma and susceptibility to tumour was analysed, to study the possible correlation between HLA class II DQA1, DQB1 and DRBI genes and melanoma in a Spanish population. Genomic DNA from 82 patients with melanoma and 367 random healthy donors, from the same geographic area, were typed by PCR-SSP (sequence specific primers). The patients were also divided into different groups according to the age and presence of cancer relatives, and compared with the controls. None of these HLA class II alleles showed significant positive or negative associations with either the overall population of patients with melanoma or the considered subgroups. Moreover, values for relative risk of DQB1*0301, DQB1*0302, DQB1*0303, DQB*05, DQA1*0401, DQA1*0101/0104 and DRB*08, which have been reported to be increased or decreased in patients with melanoma, were very low and of no statistical significance. Our results indicate that HLA class II alleles may not contribute to a strong susceptibility to melanoma in the Spanish population, although further studies on larger series are needed to corroborate this. Key words |
| Databáze: | OpenAIRE |
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