Immunocytochemical and Ultrastructural Abnormalities of Islet Tissue in Patients with VIP-Producing Tumors of the Pancreas
| Autor: | Daniele Bani, T. Bani Sacchi, G Biliotti |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Endocrinology Diabetes and Metabolism medicine.medical_treatment Vasoactive intestinal peptide Immunocytochemistry Golgi Apparatus Biology Cytoplasmic Granules Pancreatic Polypeptide Islets of Langerhans Endocrinology Internal medicine Internal Medicine medicine Humans Insulin Endocrine system geography geography.geographical_feature_category Hepatology Pancreatic Ducts Middle Aged Islet Immunohistochemistry Pancreatic Neoplasms Microscopy Electron medicine.anatomical_structure Somatostatin Gastrointestinal hormone Female Vipoma Pancreas |
| Zdroj: | Pancreas. 7:601-610 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-199209000-00014 |
| Popis: | Nontumoral endocrine pancreas from three patients with malignant vasoactive intestinal polypeptide (VIP)-omas and the Verner-Morrison (watery diarrhea, hypokalemia, and hypoachlorhydria) syndrome was studied immunocytochemically, ultrastructurally, and morphometrically. Compared with normal islets from control subjects, those of the VIPoma-associated pancreas showed a decrease of immunoreactive insulin in B-cells associated with cytological features indicative of enhanced insulin synthesis and secretion and an increase in the number of immunoreactive somatostatin- and pancreatic polypeptide-containing cells, in the absence of ultrastructural signs of modified secretory activity. No substantial alterations of A-cells were observed. In addition, images of diffuse de novo formation of ducts and islet tissue were often found. Possible mechanisms involved in determining the above changes are discussed. |
| Databáze: | OpenAIRE |
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