Decoding the infrastructure of the cerebellum
Autor: | Willem Sebastiaan van Hoogstraten, Chris I. De Zeeuw |
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Přispěvatelé: | Neurosciences, Netherlands Institute for Neuroscience (NIN) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Cerebellum Mouse Computer science QH301-705.5 brain Science Motor Activity Olivary Nucleus General Biochemistry Genetics and Molecular Biology Mice Purkinje Cells arousal medicine cerebellar cognitive affective syndrome Animals Biology (General) Projection (set theory) vestibular General Immunology and Microbiology autonomic General Neuroscience aldolase C General Medicine medicine.disease zebrin Mice Inbred C57BL medicine.anatomical_structure Cerebellar Nuclei Cerebellar cognitive affective syndrome aarousal Medicine Female Insight Neuroscience Decoding methods Cerebellar Vermis Research Article |
Zdroj: | eLife, 9:e60852. eLife Sciences Publications eLife, Vol 9 (2020) eLife |
ISSN: | 2050-084X |
Popis: | The cerebellar vermis, long associated with axial motor control, has been implicated in a surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably little is known, however, about the specific cell types and neural circuits responsible for these diverse functions. Here, using single-cell gene expression profiling and anatomical circuit analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, we identify five major classes of glutamatergic projection neurons distinguished by gene expression, morphology, distribution, and input-output connectivity. Each fastigial cell type is connected with a specific set of Purkinje cells and inferior olive neurons and in turn innervates a distinct collection of downstream targets. Transsynaptic tracing indicates extensive disynaptic links with cognitive, affective, and motor forebrain circuits. These results indicate that diverse cerebellar vermis functions could be mediated by modular synaptic connections of distinct fastigial cell types with posturomotor, oromotor, positional-autonomic, orienting, and vigilance circuits. |
Databáze: | OpenAIRE |
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