Triterpenes from Agarista Mexicana as potential antidiabetic agents
| Autor: | Perez G Rm, Vargas S R |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Blood Glucose
Male Hypoglycaemic drug Magnetic Resonance Spectroscopy Tolbutamide Mice Inbred Strains Fractionation Pharmacology Body weight Terpene Mice Triterpene medicine Animals Hypoglycemic Agents Mexico Antidiabetic agents chemistry.chemical_classification Molecular Structure Plant Extracts Terpenes Drug administration Triterpenes chemistry Hyperglycemia Ericaceae Female Medicine Traditional Phytotherapy medicine.drug |
| Zdroj: | Phytotherapy Research. 16:55-58 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.966 |
| Popis: | Hypoglycaemic activity-guided fractionation together with chemical analysis led to the isolation of 12ursene and a novel triterpene 23,24 dimethyl-24-ethyl-stigmast-25-ene from the chloroform extract of the dried stem of A. mexicana. Identification was based on spectroscopic methods. The isolated triterpenes were tested for hypoglycaemic activity in normal and alloxman-diabetic CD1 mice 25–30 g at a dose of 50 mg/kg body weight. The blood glucose levels were determined before and 1.5, 3, 4.5 and 24 h after intraperitoneal drug administration. The results showed that the triterpenes produced a significant hypoglycaemic effect in normal as well as in diabetic mice. Comparison was made between the action of the triterpenes and a known hypoglycaemic drug, tolbutamide (50 mg/kg). The 12-ursene was found to be slow and less effective than tolbutamide, and the 23,24 dimethyl-24-ethyl-stigmast-25-ene was shown to be more effective than tolbutamide. Copyright 2002 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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