An Economical, Sustainable Pathway to Indole-Containing Oxindoles: Iron-Catalyzed 1,6-Conjugate Addition in Glycerol
| Autor: | Lan Tan, Abdul Malek Abdul Rahman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
atom economy
lcsh:TJ807-830 Geography Planning and Development lcsh:Renewable energy sources Resource efficiency 1 6-conjugate addition glycerol Management Monitoring Policy and Law 010402 general chemistry 01 natural sciences recycling economy Catalysis chemistry.chemical_compound iron Atom economy Glycerol lcsh:Environmental sciences resource efficient economy lcsh:GE1-350 Indole test catalysis 010405 organic chemistry Renewable Energy Sustainability and the Environment lcsh:Environmental effects of industries and plants Sustainable manufacturing Iron catalyzed sustainable pathway Combinatorial chemistry 0104 chemical sciences lcsh:TD194-195 chemistry |
| Zdroj: | Sustainability Volume 10 Issue 8 Sustainability, Vol 10, Iss 8, p 2922 (2018) |
| ISSN: | 2071-1050 |
| DOI: | 10.3390/su10082922 |
| Popis: | The search for economical, sustainable and practical pathways in synthetic science would contribute to improving resource efficiency, developing a recycling economy and driving new-type urbanization. Green synthesis has established firm ground providing the right green yardstick for development of a sustainable approach to bioactive high-added value molecules and drug discovery, and further development of sustainable manufacturing processes in the pharmaceutical industry toward a green resource efficient economy. In this study, the combination of FeCl3 and glycerol exhibits a versatile and high catalytic activity in the atom economical 1,6-conjugated addition of para-quinone methides derived from isatins with indoles using the right green yardstick. The sustainable pathway provides the preparation of bioactive indole-containing oxindoles in excellent yields with superior advantages, such as the ready availability, low price and environmentally benign character of iron catalysis, easy product separation, cheap and safe bio-renewable glycerol as a green solvent, and catalytic system recycling under mild conditions. |
| Databáze: | OpenAIRE |
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