EFFECT OF INTRATRACHEAL FIBRES EXPOSURE ON THE RAT LUNG
| Autor: | Silvia Cerna, Erzsébet Tátrai, Zuzana Kovacikova, Marta Hurbánková |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Antioxidant medicine.medical_treatment Ascorbic Acid Antioxidants General Biochemistry Genetics and Molecular Biology Andrology Superoxide dismutase chemistry.chemical_compound Administration Inhalation Animals Medicine Lung Mineral Fibers chemistry.chemical_classification Glutathione Peroxidase medicine.diagnostic_test biology Superoxide Dismutase business.industry Glutathione peroxidase Glutathione respiratory system Ascorbic acid Rats Inbred F344 Rats Trachea Bronchoalveolar lavage medicine.anatomical_structure chemistry Free fraction biology.protein business Bronchoalveolar Lavage Fluid |
| Zdroj: | Biomedical Papers. 149:363-365 |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2005.059 |
| Popis: | The changes in antioxidant status of rat lung after intratracheal instillation of stone-wool and glass fibres were studied. The animals were exposed to 2 or 8 mg of fibres for 4 or 16 weeks, the bronchoalveolar lavage was performed and the activity of superoxide dismutase, glutathione peroxidase and the total amount of glutathione was estimated both in tissue and in cell free fraction of bronchoalveolar lavage and the ascorbic acid was determined in lung tissue. The results showed the higher burden by stone-wool. Most changes were detected in groups exposed to higher dose of fibres for shorter time period, the most sensitive parameter was superoxide dismutase. The lung tissue was studied also by light microscopy and transmission electron microscopy. |
| Databáze: | OpenAIRE |
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