Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir
| Autor: | Stefan S. Biel, Andreas Kurth, T. K. Held, Andreas Nitsche, Wolfgang Siegert, Hans R. Gelderblom, S Chen |
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| Rok vydání: | 2000 |
| Předmět: |
Male
viruses medicine.medical_treatment Organophosphonates Cytomegalovirus medicine.disease_cause Antiviral Agents Herpesviridae Cytosine chemistry.chemical_compound Organophosphorus Compounds Betaherpesvirinae Cystitis medicine Humans Hematuria Transplantation Chemotherapy biology business.industry Papillomavirus Infections virus diseases Hematology Middle Aged medicine.disease biology.organism_classification BK virus Probenecid chemistry BK Virus Cytomegalovirus Infections Immunology Virus Activation business Cidofovir medicine.drug Hemorrhagic cystitis |
| Zdroj: | Bone Marrow Transplantation. 26:347-350 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1702487 |
| Popis: | Hemorrhagic cystitis (HC) is a common complication following high-dose chemotherapy and bone marrow transplantation, and the treatment of virus-associated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decrease in viruria and to sustained suppression of CMV reactivation. Administered with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects. |
| Databáze: | OpenAIRE |
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