Circulating microRNA plasma profile in MuSK+ myasthenia gravis
| Autor: | Janice M. Massey, Vern C. Juel, Lisa D. Hobson-Webb, James F. Howard, Jeffrey T. Guptill, Liis Sabre, Anna Rostedt Punga, Melissa A. Russo |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Immunology Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Myasthenia Gravis microRNA medicine Humans Immunology and Allergy Receptors Cholinergic Circulating MicroRNA Autoantibodies biology business.industry Receptor Protein-Tyrosine Kinases MicroRNA Profile Middle Aged medicine.disease Myasthenia gravis 030104 developmental biology Neurology Cohort biology.protein Biomarker (medicine) Female Neurology (clinical) Antibody business Tyrosine kinase 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmunology. 325:87-91 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2018.10.003 |
| Popis: | Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG. |
| Databáze: | OpenAIRE |
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