Direct CNS administration of rituximab and epratuzumab in a pediatric patient with relapsed refractory CNS B‐cell acute lymphoblastic leukemia

Autor:	Jenna McClane, Anjulika Chawla, Jennifer J. G. Welch
Rok vydání:	2022
Předmět:	Adolescent Oncology Pediatrics Perinatology and Child Health Antibodies Monoclonal Humans Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies Monoclonal Humanized Child Rituximab
Zdroj:	Pediatric Blood & Cancer. 69
ISSN:	1545-5017 1545-5009
DOI:	10.1002/pbc.29664
Popis:	Relapsed central nervous system (CNS) leukemia presents a therapeutic challenge to pediatric oncologists. Systemic monoclonal antibody therapy has shown recent promise in patients with relapsed acute lymphoblastic leukemia, however its effect on CNS disease in this population is not well established. We describe a case of multiply relapsed and refractory CNS leukemia in an adolescent patient who responded to the intra-CNS delivery of rituximab (anti-CD20) and epratuzumab (anti-CD22) therapy, demonstrating the practical use and potential efficacy of a novel route of monoclonal antibody administration in difficult-to-treat CNS leukemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5586d7529f983533d0e4957180bc52a https://doi.org/10.1002/pbc.29664 Zobrazit plný text záznamu Plný text