Bleomycin-induced mutagen sensitivity, passive smoking, and risk of breast cancer in Chinese women: a case-control study
| Autor: | Shengron Sun, Dingfen Han, Yunfeng Zhou, Ming-bai Hu, Jingwei Zhang, Yaqun Yan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Passive smoking Mutagen Breast Neoplasms Bleomycin medicine.disease_cause Tobacco smoke chemistry.chemical_compound Breast cancer Asian People Internal medicine medicine Humans Genetic Predisposition to Disease Lymphocytes Aged Antibiotics Antineoplastic business.industry Mutagenicity Tests Case-control study Cancer Odds ratio Middle Aged medicine.disease Prognosis chemistry Case-Control Studies Female Tobacco Smoke Pollution business Mutagens |
| Zdroj: | Cancer causescontrol : CCC. 24(4) |
| ISSN: | 1573-7225 |
| Popis: | It is well recognized that genetic variation as well as environmental factors modulates breast cancer risk. Deficiencies in DNA repair capacity are thought to associate with breast cancer risk. The main aim of this study was to use the mutagen sensitivity assay as an indirect measure of DNA repair capacity to assess breast cancer risk and the relationship between passive smoking and breast cancer risk among women in China. We carried out a case–control study, involving 196 Chinese patients with breast cancer and 211 controls without the disease and with no history of cancer. We investigated the association between mutagen sensitivity and breast cancer risk using bleomycin as the mutagen. Mutagen sensitivity was measured by quantifying the chromatid breaks induced by mutagens in short-term cultures of peripheral blood lymphocytes. Nonparametric tests and the Fisher’s exact test were used to determine the statistical significance of the crude case–control comparisons, followed by logistic regression to adjust for important covariates. The mean number of bleomycin-induced breaks per cell was 0.81 for cases compared with 0.73 for the controls (p = 0.016). A greater number of bleomycin-induced chromosomal breaks per cell was associated with an increased risk of breast cancer (adjusted odds ratio of 1.82, p trend |
| Databáze: | OpenAIRE |
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