fMLP-OMe analogs substituted at the methionine residue: an insight into the receptor properties

Autor:	Giorgio Cavicchioni, Susanna Spisani, Maria Enrica Ferretti, Lara G. Monesi, Elena Fabbri, Olivia Rizzuti
Rok vydání:	1999
Předmět:	chemistry.chemical_classification Methionine Chemotactic Factors Receptors Peptide Stereochemistry Neutrophils Pharmaceutical Science hemic and immune systems Peptide Tripeptide Ligand (biochemistry) Chemical synthesis Receptors Formyl Peptide N-Formylmethionine Leucyl-Phenylalanine Residue (chemistry) chemistry.chemical_compound Structure-Activity Relationship chemistry Drug Discovery Peptide synthesis Humans Receptors Immunologic Receptor
Zdroj:	Archiv der Pharmazie. 331(11)
ISSN:	0365-6233
Popis:	In order to obtain an insight into the mode of binding at the for-Met-Leu-Phe-OH (fMLP) receptor, three fMLP-OMe analogs (1-3) were synthesized in which the Met residue was substituted by Gln 1, Asn 2, and Ser 3. We evaluated the influence of the charge variation and/or the shift of its position on neutrophil biological responses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d556371db0809545626c30758bccf5b0 https://pubmed.ncbi.nlm.nih.gov/9881061 Zobrazit plný text záznamu Plný text