Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
| Autor: | Masahiro Ogawa, Yuki Inada, Atsushi Iwata, Kohei Tashiro, Tomo Komaki, Motoki Yamashita, Eriko Morishita, Shin-ichiro Miura |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Antithrombin III Hereditary Antithrombin Deficiency Drug Resistance Case Report 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Internal Medicine Humans Medicine cardiovascular diseases negative family history of thrombosis Family history deep venous thrombosis Genetic testing Venous Thrombosis Antithrombin III Deficiency medicine.diagnostic_test Heparin business.industry hereditary antithrombin deficiency General Medicine medicine.disease Thrombosis Second pregnancy Venous thrombosis Mutation Gestation Female 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.3268-19 |
| Popis: | A 37-year-old woman developed deep venous thrombosis (DVT) of the left lower extremity at 8 weeks of gestation during her second pregnancy. There was no personal or family history of thrombosis. She received intravenous heparin, but heparin resistance was noted. The plasma antithrombin activity decreased to 45% in the acute phase, and it remained low postpartum. Her mother also had low plasma antithrombin activity (46%), and genetic testing revealed a heterozygous SERPINC1 mutation. Even without a family history of thrombosis, we should suspect hereditary antithrombin deficiency in patients with initial DVT and perform thorough investigation. |
| Databáze: | OpenAIRE |
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