Potential application of cell reprogramming techniques for cancer research
| Autor: | Ying-Chu Lin, Chang-Shen Lin, Kazunari K. Yokoyama, Shigeo Saito, Yukio Nakamura, Richard Eckner, Kung-Kai Kuo, Kenly Wuputra |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Review
Biology Regenerative medicine Epigenesis Genetic 03 medical and health sciences Cellular and Molecular Neuroscience Cancer stem cell Neoplasms medicine Organoid culture Tumor Microenvironment Animals Humans Cellular Reprogramming Techniques Induced pluripotent stem cell Molecular Biology Pharmacology Somatic cell nuclear transfer 0303 health sciences Cancer stem cells 030302 biochemistry & molecular biology Cancer Cell Biology medicine.disease Cellular Reprogramming Gene Expression Regulation Neoplastic Induced pluripotent stem cells Cancer cell Cancer research Neoplastic Stem Cells Molecular Medicine Epigenetics Stem cell Reactive oxygen species Reprogramming |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-9071 1420-682X |
| Popis: | The ability to control the transition from an undifferentiated stem cell to a specific cell fate is one of the key techniques that are required for the application of interventional technologies to regenerative medicine and the treatment of tumors and metastases and of neurodegenerative diseases. Reprogramming technologies, which include somatic cell nuclear transfer, induced pluripotent stem cells, and the direct reprogramming of specific cell lineages, have the potential to alter cell plasticity in translational medicine for cancer treatment. The characterization of cancer stem cells (CSCs), the identification of oncogene and tumor suppressor genes for CSCs, and the epigenetic study of CSCs and their microenvironments are important topics. This review summarizes the application of cell reprogramming technologies to cancer modeling and treatment and discusses possible obstacles, such as genetic and epigenetic alterations in cancer cells, as well as the strategies that can be used to overcome these obstacles to cancer research. |
| Databáze: | OpenAIRE |
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