Novel nano-pomegranates based on astragalus polysaccharides for targeting ERα-positive breast cancer and multidrug resistance
Autor: | Bingjie Wang, Yanchun Zhang, Yanhui Liu, Chunjing Guo, Haiyu Xu, Daquan Chen, Yi Li, Guangting Han |
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Rok vydání: | 2020 |
Předmět: |
Curcumin
medicine.medical_treatment Mice Nude Pharmaceutical Science Breast Neoplasms RM1-950 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences Drug Delivery Systems Folic Acid 0302 clinical medicine Breast cancer chemotherapy Breast cancer Polysaccharides multidrug resistance nano-pomegranates medicine Animals Humans targeting erα-positive breast cancer skin and connective tissue diseases Drug Carriers Chemotherapy business.industry Estrogen Receptor alpha technology industry and agriculture Astragalus Plant General Medicine 021001 nanoscience & nanotechnology medicine.disease Xenograft Model Antitumor Assays Drug Resistance Multiple Multiple drug resistance Drug Liberation astragalus polysaccharides Astragalus polysaccharide Drug Resistance Neoplasm MCF-7 Cells Cancer research Nanoparticles Female Quercetin Therapeutics. Pharmacology 0210 nano-technology business Research Article |
Zdroj: | Drug Delivery, Vol 27, Iss 1, Pp 607-621 (2020) Drug Delivery |
ISSN: | 1521-0464 1071-7544 |
Popis: | Chemotherapy is an important method for treating breast cancer. However, multidrug resistance is one of the major challenges in breast cancer chemotherapy. There is an urgent need to develop novel, effective antitumor strategies that will perfect existing therapeutic regimens. In this study, the double-targeted nanocarrier, Quercetin-3’3-dithiodipropionic acid-Astragalus polysaccharides-Folic acid (QDAF), was successfully synthesized and self-assembled into a neoteric nano-targeted delivery strategy, named nano-pomegranates, and which were utilized to effectively inhibit multidrug resistance in estrogen receptor α (ERα)-positive breast tumor. The outstanding abilities of nano-pomegranates to release the drug in a reducing environment was determined by in vitro release assay. The cellular studies in MCF-7 cells were examined that nano-pomegranates have remarkable efficiencies of enhancing cellular uptake, inhibition and necrosis and apoptosis. In vivo antitumor experiments showed that nano-pomegranates have better anti-tumor effects and lower systemic toxicity than free Cur. In conclusion, nano-pomegranates have great potential in anti-breast cancer treatment. |
Databáze: | OpenAIRE |
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