Novel nano-pomegranates based on astragalus polysaccharides for targeting ERα-positive breast cancer and multidrug resistance

Autor: Bingjie Wang, Yanchun Zhang, Yanhui Liu, Chunjing Guo, Haiyu Xu, Daquan Chen, Yi Li, Guangting Han
Rok vydání: 2020
Předmět:
Curcumin
medicine.medical_treatment
Mice
Nude
Pharmaceutical Science
Breast Neoplasms
RM1-950
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
Drug Delivery Systems
Folic Acid
0302 clinical medicine
Breast cancer chemotherapy
Breast cancer
Polysaccharides
multidrug resistance
nano-pomegranates
medicine
Animals
Humans
targeting erα-positive breast cancer
skin and connective tissue diseases
Drug Carriers
Chemotherapy
business.industry
Estrogen Receptor alpha
technology
industry
and agriculture
Astragalus Plant
General Medicine
021001 nanoscience & nanotechnology
medicine.disease
Xenograft Model Antitumor Assays
Drug Resistance
Multiple
Multiple drug resistance
Drug Liberation
astragalus polysaccharides
Astragalus polysaccharide
Drug Resistance
Neoplasm
MCF-7 Cells
Cancer research
Nanoparticles
Female
Quercetin
Therapeutics. Pharmacology
0210 nano-technology
business
Research Article
Zdroj: Drug Delivery, Vol 27, Iss 1, Pp 607-621 (2020)
Drug Delivery
ISSN: 1521-0464
1071-7544
Popis: Chemotherapy is an important method for treating breast cancer. However, multidrug resistance is one of the major challenges in breast cancer chemotherapy. There is an urgent need to develop novel, effective antitumor strategies that will perfect existing therapeutic regimens. In this study, the double-targeted nanocarrier, Quercetin-3’3-dithiodipropionic acid-Astragalus polysaccharides-Folic acid (QDAF), was successfully synthesized and self-assembled into a neoteric nano-targeted delivery strategy, named nano-pomegranates, and which were utilized to effectively inhibit multidrug resistance in estrogen receptor α (ERα)-positive breast tumor. The outstanding abilities of nano-pomegranates to release the drug in a reducing environment was determined by in vitro release assay. The cellular studies in MCF-7 cells were examined that nano-pomegranates have remarkable efficiencies of enhancing cellular uptake, inhibition and necrosis and apoptosis. In vivo antitumor experiments showed that nano-pomegranates have better anti-tumor effects and lower systemic toxicity than free Cur. In conclusion, nano-pomegranates have great potential in anti-breast cancer treatment.
Databáze: OpenAIRE
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