Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's disease
Autor: | Giovanni Fabbrini, Francesco Amenta, Gian Luigi Lenzi, Giuseppe Bruno, Alberto Ricci, Piero Barbanti, Elena Bronzetti, Rosanna Cerbo |
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Rok vydání: | 2000 |
Předmět: |
Male
Aging Psychosis medicine.medical_specialty Tetrahydronaphthalenes In Vitro Techniques Radioligand Assay Dopamine receptor D1 Alzheimer Disease Dopamine receptor D3 Dopamine Internal medicine Dopamine receptor D2 medicine Humans heterocyclic compounds Lymphocytes Receptor Aged Aged 80 and over Receptors Dopamine D2 Chemistry Receptors Dopamine D1 Dopaminergic Benzazepines Middle Aged medicine.disease Kinetics Endocrinology Dopamine receptor Case-Control Studies Dopamine Agonists Dopamine Antagonists Female Developmental Biology medicine.drug |
Zdroj: | Mechanisms of Ageing and Development. 120:65-75 |
ISSN: | 0047-6374 |
Popis: | Clinical and pathological evidence points to an involvement of dopamine in Alzheimer's disease (AD). The present study was designed to assay dopamine D1-like and D2-like receptors on peripheral blood lymphocytes (PBL) in 20 patients with AD and in 25 healthy controls by radioligand binding assay techniques with [ 3 H][R]-(+)-(−)chloro-2,3,4,5 tetrahydro-5-phenyl-1H-3-benzazepin-al-hemimaleate (SCH 23390) and [ 3 H]7-hydroxy- N , N -di- n -propyl-2-aminotetraline (7OH-DPAT) as radioligands. The density of dopamine D1-like receptors and the affinity of [ 3 H]SCH 23390 and [ 3 H]7OH-DPAT binding to PBL were similar in both groups investigated. AD patients revealed a lower density of dopamine D2-like receptors on PBL than controls ( P =0.0016). The pharmacological profile of [ 3 H]SCH 23390 and [ 3 H]7OH-DPAT binding to PBL was consistent with the labeling of dopamine D5 and D3 receptor subtypes, respectively. The reduced density of dopamine D2-like receptors on PBL is consistent with the observation of changes in the expression of D2-like receptors in dopaminergic brain areas in AD. Our findings support the hypothesis of an involvement of dopamine in AD, even in those patients with no evidence of Parkinsonism, behavioral abnormalities or psychosis. |
Databáze: | OpenAIRE |
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