Quantitative 1H and hyperpolarized 3He magnetic resonance imaging: Comparison in chronic obstructive pulmonary disease and healthy never-smokers
| Autor: | Andrew Wheatley, David G. McCormack, Grace Parraga, Amir Owrangi, Jian X. Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Spirometry Arbitrary unit Static Electricity Contrast Media Pulmonary disease Helium Sensitivity and Specificity Pulmonary function testing Pulmonary Disease Chronic Obstructive Reference Values Image Interpretation Computer-Assisted Magentic resonance imaging 1H MR signal intensity Humans Medicine Plethysmograph Effective diffusion coefficient Radiology Nuclear Medicine and imaging Aged Emphysema COPD medicine.diagnostic_test business.industry Smoking Reproducibility of Results Hyperpolarized 3He Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Respiratory Function Tests Apparent diffusion coefficient Pulmonary Emphysema Medical Biophysics Female Protons business Nuclear medicine |
| Zdroj: | Medical Biophysics Publications |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2012.02.018 |
| Popis: | Objective The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1 H magnetic resonance imaging (MRI) signal intensity (SI) and 3 He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1 H and diffusion-weighted hyperpolarized 3 He MRI ( b = 1.6 s/cm 2 ) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results Mean 1 H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1 H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R 2 = 0.94) compared to COPD subjects (0.29 AU/cm, R 2 = 0.968, p = 0.05). There was a significant correlation between 1 H SI and 3 He ADC ( r = −0.58, p = 0.008) and significant correlations between 1 H MR SI and CT measurements of emphysema (RA 950 , r = −0.69, p = 0.02 and HU 15 , r = 0.66, p = 0.03). Conclusions The significant and moderately strong relationship between 1 H SI and 3 He ADC, as well as between 1 H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1 H SI may be used to monitor emphysema as a complement to CT and noble gas MRI. |
| Databáze: | OpenAIRE |
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