Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort
| Autor: | Jerel M. Ezell, Rana Tawil Misiak, Charlotte Nicholas, Edward M. Zoratti, Christine L.M. Joseph, Suzanne Havstad, Christine Cole Johnson, Dennis R. Ownby, Christian G. Nageotte, Robert Enberg |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Allergy Pediatrics medicine.medical_specialty Immunology Ethnic group Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Food allergy 030225 pediatrics Environmental health Ethnicity Odds Ratio Prevalence medicine Animals Humans Immunology and Allergy Skin Tests business.industry digestive oral and skin physiology Infant Newborn Infant Emergency department Odds ratio Allergens Immunoglobulin E medicine.disease 030228 respiratory system Child Preschool Female Racial differences business Birth cohort Food Hypersensitivity Cohort study |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 116:219-224.e1 |
| ISSN: | 1081-1206 |
| DOI: | 10.1016/j.anai.2015.12.019 |
| Popis: | Suspected food allergies are the cause of more than 200,000 visits to the emergency department annually. Racial differences in the prevalence of food allergy have also been reported, but the evidence is less conclusive. Researchers continue to struggle with the identification of food allergy for epidemiologic studies.To explore racial differences in IgE-mediated food allergy (IgE-FA) in a birth cohort.We used a panel of board-certified allergists to systematically identify IgE-FA to egg, milk, or peanut in a multiethnic birth cohort in which patient medical history, patient symptoms, and clinical data were available through 36 months of age.Of the 590 infants analyzed, 52.9% were male and 65.8% African American. Sensitization (serum specific IgE0.35 IU/mL) to the food allergens was significantly higher for African American children compared with non-African American children as has been previously reported. No statistically significant racial/ethnic differences in IgE-FA were observed; however, a higher proportion of African American children were designated as having peanut allergy, and the percentage of African American children with an IgE level greater than 95% predictive decision points for peanut was 1.7% vs 0.5% for non-African American children. With the use of logistic regression, race/ethnicity was not significantly associated with IgE-FA (adjusted odds ratio, 1.12; 95% confidence interval, 0.58-2.17; P = .75) but was associated with sensitization to more than 1 of the food allergens (adjusted odds ratio, 1.80; 95% confidence interval, 1.22-2.65; P = .003).We did not observe an elevated risk of IgE-FA for African American children, although established differences in sensitization were observed. Racial/ethnic differences in sensitization must be taken into consideration when investigating disparities in asthma and allergy. |
| Databáze: | OpenAIRE |
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