Improved Pregnancy Outcome in Patients With Rheumatoid Arthritis Who Followed an Ideal Clinical Pathway
| Autor: | Véronique Ramoni, F. Rumi, Greta Carrara, And Carlo Alberto Scirè, Angela Tincani, Alessandra Bortoluzzi, Laura Andreoli, Marcello Govoni, Melissa Padovan |
|---|---|
| Přispěvatelé: | Bortoluzzi, A, Andreoli, L, Carrara, G, Ramoni, V, Rumi, F, Padovan, M, Govoni, M, Tincani, A, Scire, C |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Rheumatoid Arthritis Clinical Pathway Adolescent Databases Factual Population Rheumatoid Arthritis Risk Assessment Pregnancy outcome Miscarriage Arthritis Rheumatoid Young Adult 03 medical and health sciences 0302 clinical medicine Clinical pathway Rheumatology Risk Factors Pregnancy Internal medicine Adverse Outcome Pathway Quality Indicator Humans Medicine education Retrospective Studies 030203 arthritis & rheumatology education.field_of_study Adverse Outcome Pathways business.industry Ambientale Retrospective cohort study Odds ratio Middle Aged medicine.disease Administrative Health Database Abortion Spontaneous Pregnancy Complications Cohort Critical Pathways Female business |
| Popis: | Objective To assess the effect of optimal management of pregnancy on a composite outcome of miscarriage and complicated birth among women with rheumatoid arthritis (RA). Methods Data were extracted from health care databases of the Lombardy Region, Italy (2004-2013) as a part of the Record-Linkage on Rheumatic Diseases Study. Analyses included women with RA identified through a copayment exemption code (International Classification of Diseases, Ninth Revision, Clinical Modification code 714.0) and controls from the general population, ages 18-50 years. Seven health care quality indicators (HCQI) were constructed and summarized in 3 pathway indicators: diagnostic, therapeutic, and prenatal follow-up. Complicated birth or miscarriage were used to identify the adverse pregnancy outcome (APO). The relationship between HCQI and APO was analyzed using logistic models, and the results were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results Data from the study cohort included the first pregnancy observed in 443 patients with RA compared with 6,097 women belonging to the general population. In the RA population, patients who followed the 3 pathway indicators had a reduced risk of overall APO, with an OR of 0.60 (95% CI 0.39-0.94), and reduced risk of miscarriage/perinatal death, with an OR of 0.40 (95% CI 0.24-0.69), compared to those who did not follow the pathway indicators. Compared with the general population, patients with RA who met all HCQI during pregnancy displayed a risk of APO with an OR of 0.92 (95% CI 0.61-1.38) and miscarriage/perinatal death with an OR of 0.77 (95% CI 0.47-1.29). Conclusion The adherence to an ideal clinical pathway of pregnancy management in women with RA restored the risk of APO to that expected for the general population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|