| Autor: |
Antoine Assaf, Benoit Terris, Lola-Jade Palmieri, Alexandre Rouquette, Frédéric Beuvon, Anna Pellat, Einas Abou Ali, Claire Ginestet, Arthur Belle, Dr Marion Dhooge, Dr Catherine Brezault, Rachel Hallit, Anthony Dohan, Stanislas Chaussade, Romain Coriat, Maximilien Barret |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinics and Research in Hepatology and Gastroenterology. 46:101903 |
| ISSN: |
2210-7401 |
| DOI: |
10.1016/j.clinre.2022.101903 |
| Popis: |
Gastric linitis plastica (GLP) is a diffuse infiltrating type of gastric adenocarcinoma. It is associated with a poor prognosis and a five-year survival of 3-10%. The infiltrating profile of this tumor explains the low yield of the superficial mucosal biospies. The objective of this study was to investigate the role of endoscopic ultrasound-fine needle biopsy (EUS-FNB) in the diagnosis of GLP.We performed a retrospective analysis including all patients who had an EUS-FNB, at a tertiary referral center, over the last 3 years. The primary outcome was the sensitivity of EUS-FNB in patients with suspected GLP.Between January 2017 and December 2020, 34 patients had an EUS-FNB for suspected GLP. Ten patients had a diagnostic of GLP. This diagnosis was obtained by EUS-FNB in 90% (9/10) of the cases. Eight patients had at least one previous esophagogastroduodenoscopy (EGD) with negative mucosal biopsies. Gastric EUS-FNB helped diagnose other serious conditions in 47% (16/34) of cases with inconclusive mucosal biopsies.Gastric EUS-FNB in patients with suspected GLP and normal endoscopic mucosal biopsies may lead to a positive diagnosis of GLP in 90% of cases without notable adverse events. This technique should be considered as a second step in the setting of suspicion of GLP after inconclusive mucosal biopsies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect