Plectin in the central nervous system and a putative role in brain astrocytes
| Autor: | Jernej Jorgačevski, Maja Potokar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Gene isoform
Cell type intermediate filaments plectin QH301-705.5 glia Central nervous system neurons Review macromolecular substances Biology microtubules Microtubule medicine plektin Animals Humans Biology (General) Cytoskeleton Intermediate filament Actin centralni živčni sistem astrociti astrocytes Brain cytolinker proteins General Medicine Plectin central nervous system medicine.anatomical_structure udc:616-092 actin filaments Neuroglia Neuroscience |
| Zdroj: | Cells, vol. 10, no. 9, 2353, 2021. Cells, Vol 10, Iss 2353, p 2353 (2021) Cells |
| ISSN: | 2073-4409 |
| Popis: | Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of the CNS as a whole. Yet, by analogy to its role in other tissues, it is anticipated that, in the CNS, plectin also functions as the key cytoskeleton interlinking molecule. Thus, it is likely involved in signalling processes, thereby affecting numerous fundamental functions in the brain and spinal cord. Versatile direct and indirect interactions of plectin with cytoskeletal filaments and enzymes in the cells of the CNS in normal physiological and in pathologic conditions remain to be fully addressed. Several pathologies of the CNS related to plectin have been discovered in patients with plectinopathies. However, in view of plectin as an integrator of a cohesive mesh of cellular proteins, it is important that the role of plectin is also considered in other CNS pathologies. This review summarizes the current knowledge of plectin in the CNS, focusing on plectin isoforms that have been detected in the CNS, along with its expression profile and distribution alongside diverse cytoskeleton filaments in CNS cell types. Considering that the bidirectional communication between neurons and glial cells, especially astrocytes, is crucial for proper functioning of the CNS, we place particular emphasis on the known roles of plectin in neurons, and we propose possible roles of plectin in astrocytes. |
| Databáze: | OpenAIRE |
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