Myoinositol, glucose and zinc status as risk factors for non-syndromic cleft lip with or without cleft palate in offspring: a case-control study

Autor: Ingrid P.C. Krapels, Régine P.M. Steegers-Theunissen, Iris A.L.M. van Rooij, Gerhard A. Zielhuis, Paul H.M. Spauwen, Ron A. Wevers, Wim Brussel
Přispěvatelé: Obstetrics & Gynecology
Rok vydání: 2004
Předmět:
Adult
Blood Glucose
Male
Tissue engineering and reconstructive surgery [UMCN 4.3]
medicine.medical_specialty
Erythrocytes
Offspring
Cleft Lip
Folic Acid
Pregnancy
Risk Factors
Interventional oncology [UMCN 1.5]
Internal medicine
medicine
Determinants in Health and Disease [EBP 1]
Humans
Risk factor
business.industry
Endocrinology and reproduction [UMCN 5.2]
Case-control study
Effective Hospital Care [EBP 2]
Infant
Obstetrics and Gynecology
Venous blood
Odds ratio
medicine.disease
Neuromuscular development and genetic disorders [UMCN 3.1]
Cleft Palate
Pregnancy Complications
Zinc
Red blood cell
Endocrinology
medicine.anatomical_structure
Genetic defects of metabolism [UMCN 5.1]
Case-Control Studies
Prenatal Exposure Delayed Effects
Dietary Supplements
Zinc deficiency
Female
business
Inositol
Zdroj: British Journal of Obstetrics and Gynaecology, 111, 661-668. Wiley-Blackwell Publishing Ltd
BJOG : an International Journal of Obstetrics and Gynaecology, 111, 661-8
BJOG : an International Journal of Obstetrics and Gynaecology, 111, 7, pp. 661-8
ISSN: 1471-0528
1470-0328
0306-5456
Popis: Contains fulltext : 58709.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To investigate myo-inositol, glucose and zinc status in mothers and their infants on cleft lip with or without cleft palate risk (CLP). DESIGN: Case-control study. SETTING: University Medical Centre Nijmegen, the Netherlands. POPULATION: Eighty-four mothers and their CLP child and 102 mothers and their healthy child. METHODS: Venous blood samples were obtained to determine serum myo-inositol and glucose and red blood cell zinc concentrations in mothers and children. Geometric means were calculated and compared between the groups. The blood parameters were dichotomised with cutoff points based on control values, P90 for glucose concentrations. MAIN OUTCOME MEASURES: Geometric means (P5-P95) and odds ratios (95% confidence intervals). RESULTS: The CLP children (P= 0.003) and their mothers (P= 0.02) had significantly lower red blood cell zinc concentrations than controls. A low maternal serum myo-inositol concentration (
Databáze: OpenAIRE
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