Volumetric magnetic resonance imaging analysis in patients with short-term remission of Cushing's disease
| Autor: | Hong Jiang, Naying He, Si-Jian Pan, Yuhao Sun, Fangfang Jian, Jian-kang Shen, Fuhua Yan, Jie Ren, Liuguan Bian, Chang Liu, Qingfang Sun |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Prefrontal Cortex 030209 endocrinology & metabolism Grey matter 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Internal medicine medicine Humans In patient Pituitary ACTH Hypersecretion Cushing Syndrome business.industry Cushing's disease Voxel-based morphometry Medial frontal gyrus Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Cross-Sectional Studies Remission duration Volumetric magnetic resonance imaging Curative surgery Female business 030217 neurology & neurosurgery |
| Zdroj: | Clinical endocrinology. 87(4) |
| ISSN: | 1365-2265 |
| Popis: | SummaryObjective The data on patients with short-term remission of Cushing's disease (CD) might provide information that is not available from previous long-term remission studies. We aimed to investigate structural changes in the brain in these patients and to examine whether these changes were associated with clinical characteristics. Design A cross-sectional study was performed. Methods Thirty-four CD patients (14 with CD in short-term remission and 20 with active CD) and 34 controls matched for age, sex, and education underwent clinical evaluation and magnetic resonance imaging brain scans. Biometric measurements, disease duration and remission duration data were collected. Grey matter volumes in the whole brain were examined using voxel-based morphometry (VBM). Results No differences were observed in the grey matter volumes of the medial frontal gyrus (MFG) and cerebellum between the patients with remitted CD and healthy controls, whereas patients with active CD had smaller grey matter volumes in these two regions compared with controls and patients with remitted CD. Furthermore, significant correlations were found between remission time and grey matter values in these regions in short-term remission CD patients. Additionally, greater grey matter volumes in the bilateral caudate of short-term remission CD patients were observed. Conclusions Trends for structural restoration were found in CD patients with short-term remission. This finding was associated with the number of days elapsed since curative surgery and the current age of the patients. This study enhances our understanding of potential reversibility after the resolution of hypercortisolism in CD patients. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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