Coffee consumption and the risk of malignant melanoma in the Norwegian Women and Cancer (NOWAC) Study
| Autor: | Marko Lukic, Elisabete Weiderpass, Tonje Braaten, Mie Jareid |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research Sunburn Coffee Filtered 0302 clinical medicine Risk Factors Surveys and Questionnaires Prospective Studies Registries Prospective cohort study Melanoma Norway Incidence Incidence (epidemiology) Hazard ratio Middle Aged VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Dermatology and venereology: 753 030220 oncology & carcinogenesis Female Risk assessment Research Article Adult medicine.medical_specialty Drinking Behavior Lower risk Risk Assessment 03 medical and health sciences Internal medicine Genetics medicine Humans Aged Proportional Hazards Models Instant 030109 nutrition & dietetics VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 business.industry Proportional hazards model VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Dermatologi og venerologi: 753 Cancer Prospective cohort medicine.disease Confidence interval Surgery VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 Multivariate Analysis Multiple imputation Boiled business Follow-Up Studies |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-016-2586-5 |
| Popis: | Background Coffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma. We studied the impact of total coffee consumption and of different brewing methods on the incidence of malignant melanoma in a prospective cohort of Norwegian women. Methods We had baseline information on total coffee consumption and consumption of filtered, instant, and boiled coffee from self-administered questionnaires for 104,080 women in the Norwegian Women and Cancer (NOWAC) Study. We also had follow-up information collected 6–8 years after baseline. Multiple imputation was used to deal with missing data, and multivariable Cox regression models were used to calculate hazard ratios (HR) for malignant melanoma by consumption category of total, filtered, instant, and boiled coffee. Results During 1.7 million person-years of follow-up, 762 cases of malignant melanoma were diagnosed. Compared to light consumers of filtered coffee (≤1 cup/day), we found a statistically significant inverse association with low-moderate consumption (>1–3 cups/day, HR = 0.80; 95 % confidence interval [CI] 0.66–0.98) and high-moderate consumption of filtered coffee (>3–5 cups/day, HR = 0.77; 95 % CI 0.61–0.97) and melanoma risk (ptrend = 0.02). We did not find a statistically significant association between total, instant, or boiled coffee consumption and the risk of malignant melanoma in any of the consumption categories. Conclusions The data from the NOWAC Study indicate that a moderate intake of filtered coffee could reduce the risk of malignant melanoma. Electronic supplementary material The online version of this article (doi:10.1186/s12885-016-2586-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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