Altered hippocampal morphology in unmedicated patients with major depressive illness
| Autor: | Mark Nicoletti, Paul M. Thompson, Carrie E. Bearden, Andrea D. Klunder, Jair C. Soares, Christina Avedissian, Nicole Dierschke, Paolo Brambilla |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
hippocampus medicine.medical_treatment Hippocampus Physiology MDD major depressive disorder Hippocampal formation Brain mapping HDRS Hamilton Depression Rating Scales 0302 clinical medicine 2.1 Biological and endogenous factors Aetiology neuroimaging Depression General Neuroscience Subiculum Middle Aged Serious Mental Illness Magnetic Resonance Imaging CA cornu ammonis S12 Mental Health Major depressive disorder brain mapping Female Psychology Research Article Clinical psychology Adult medicine.drug_class Atypical antipsychotic mood disorder lcsh:RC321-571 03 medical and health sciences Atrophy Clinical Research medicine Humans unipolar depression Antipsychotic lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Depressive Disorder Major Depressive Disorder Neurosciences Major DSM-IV Diagnostic and Statistical Manual of Mental Disorders 4th Edition medicine.disease 030227 psychiatry antipsychotic Brain Disorders SCID Structured Clinical Interview for DSM-IV subiculum Neurology (clinical) MRI magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | ASN neuro, vol 1, iss 4 ASN NEURO ASN Neuro, Vol 1 (2009) |
| Popis: | Despite converging evidence that major depressive illness is associated with both memory impairment and hippocampal pathology, findings vary widely across studies and it is not known whether these changes are regionally specific. In the present study we acquired brain MRIs (magnetic resonance images) from 31 unmedicated patients with MDD (major depressive disorder; mean age 39.2±11.9 years; 77% female) and 31 demographically comparable controls. Three-dimensional parametric mesh models were created to examine localized alterations of hippocampal morphology. Although global volumes did not differ between groups, statistical mapping results revealed that in MDD patients, more severe depressive symptoms were associated with greater left hippocampal atrophy, particularly in CA1 (cornu ammonis 1) subfields and the subiculum. However, previous treatment with atypical antipsychotics was associated with a trend towards larger left hippocampal volume. Our findings suggest effects of illness severity on hippocampal size, as well as a possible effect of past history of atypical antipsychotic treatment, which may reflect prolonged neuroprotective effects. This possibility awaits confirmation in longitudinal studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|