Supramolecular hydrogels inspired by collagen for tissue engineering
| Autor: | Zhimou Yang, Jingyu Wang, Yongjun Zhang, Wang Liao, Deling Kong, Yuehan Hu, Yonggang Yang, Huaimin Wang, Sibing Wang |
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| Rok vydání: | 2010 |
| Předmět: |
Supramolecular chemistry
Nanotechnology macromolecular substances Tripeptide Naphthalenes complex mixtures Biochemistry Mice Tissue engineering Biomimetic Materials Polymer chemistry Animals Physical and Theoretical Chemistry Tissue Engineering Tissue Scaffolds Chemistry Organic Chemistry technology industry and agriculture Hydrogels Nih3t3 cell Supramolecular hydrogels Cell culture Collagen metabolism Self-healing hydrogels NIH 3T3 Cells Collagen Rheology Oligopeptides |
| Zdroj: | Organicbiomolecular chemistry. 8(14) |
| ISSN: | 1477-0539 |
| Popis: | Supramolecular hydrogels are promising biomaterials for cell culture in 2-D and 3-D environments. Inspired by the chemical structure of collagen, which bears the repeating tripeptide of glycine-Xaa-4R-hydroxyproline (GXO; Xaa is any one of the natural amino acids), we designed and synthesized a small library of supramolecular hydrogelators (a total of 6). We found that four of the hydrogels were suitable for NIH 3T3 cell culture in the 2-D environments. Gel 2, the best hydrogel, has properties that are similar to those of collagen for 3T3 cell culture. These findings not only provide more supramolecular hydrogel candidates for tissue engineering, but also offer a new strategy for designing biomaterials that mimic nature. |
| Databáze: | OpenAIRE |
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