Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report

Autor:	Shinichi Akiyama, Koki Mise, Koichi Kikuchi, Junichi Hoshino, Shoichi Maruyama, Noriko Hayami, Keiichi Kubota, Tatsuya Suwabe, Toshiharu Ueno, Masayuki Yamanouchi, Keiichi Sumida, Takeshi Fujii, Naoki Sawa, Ryo Hazue, Kenmei Takaichi, Junko Yabuuchi, Yoshifumi Ubara, Akinari Sekine, Kenichi Ohashi
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Published online: May 2016 medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Idiopathic membranous glomerulonephritis 030204 cardiovascular system & hematology Malignancy Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anti-phospholipase A2 receptor antibody Internal medicine Edema Medicine Creatinine medicine.diagnostic_test business.industry Glomerulonephritis Hepatitis B medicine.disease Elderly nephropathy chemistry Nephrology Immunology Renal biopsy Hemodialysis medicine.symptom business
Zdroj:	Case Reports in Nephrology and Dialysis
ISSN:	2296-9705
Popis:	A 95-year-old woman was admitted to our hospital for evaluation of bilateral lower-limb edema persisting for 3 months. Serum creatinine was 1.55 mg/dl, and urinary protein excretion was 9.1 g/day. Renal biopsy revealed stage 1 membranous glomerulonephritis (MGN) with immunoglobulin G4-dominant staining. This patient did not have any underlying disease such as infection with hepatitis B or C virus or malignancy, and anti-phospholipase A2 receptor (PLA2R) antibody was detected in the serum. Accordingly, idiopathic MGN was diagnosed. Corticosteroid therapy was avoided, but hemodialysis was required to treat generalized edema. The patient is currently doing well. This is the oldest reported case of idiopathic MGN with positivity for anti-PLA2R antibody.
Databáze:	OpenAIRE
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