Regulation of myostatin expression is associated with growth and muscle development in commercial broiler and DMC muscle
Autor: | Sumei Zhao, Xu Zhiqiang, Rong Hua, Dahai Gu, Huang Ying, Changrong Ge, Xiaobo Chen, Li Zhengtian, Wang Kun, Dou Tengfei, Markandeya Jois, Marinus F.W. te Pas, Jia Junjing, Liu Lixian, Jiarong Zhang, Hu Wenyuan, Li Qihua |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Muscle tissue medicine.medical_specialty animal structures Mrna expression Gene Expression Myostatin Biology Breeding Muscle Development Commercial broiler chicken Muscle hypertrophy Avian Proteins 03 medical and health sciences Internal medicine Genetics medicine Animals RNA Messenger Animal Husbandry Fokkerij & Genomica Muscle Skeletal Molecular Biology Daweishan mini chicken Uncategorized Growth rate 0402 animal and dairy science Broiler Skeletal muscle mRNA expression 04 agricultural and veterinary sciences General Medicine musculoskeletal system 040201 dairy & animal science Breed 030104 developmental biology medicine.anatomical_structure Endocrinology Phenotype Gene Expression Regulation Muscle weight biology.protein WIAS Original Article Chickens Animal Breeding & Genomics |
Zdroj: | Molecular Biology Reports, 45(4), 511-522 Molecular Biology Reports Molecular Biology Reports 45 (2018) 4 |
ISSN: | 0301-4851 |
Popis: | Myostatin is a negative regulator of skeletal muscle growth. Muscle tissue is the largest tissue in the body and influences body growth. Commercial Avian broiler chickens are selected for high growth rate and muscularity. Daweishan mini chickens are a slow growing small-sized chicken breed. We investigated the relations between muscle (breast and leg) myostatin mRNA expression and body and muscle growth. Twenty chickens per breed were slaughtered at 0, 30, 60, 90, 120, and 150 days of age. Body and muscle weights were higher at all times in Avian chickens. Breast muscle myostatin expression was higher in Avian chickens than in Daweishan mini chickens at day 30. Myostatin expression peaked at day 60 in Daweishan mini chickens and expression remained higher in breast muscle. Daweishan mini chickens myostatin expression correlated positively with carcass weight, breast and leg muscle weight from day 0 to 60, and correlated negatively with body weight from day 90 to 150, while myostatin expression in Avian chickens was negatively correlated with carcass and muscle weight from day 90 to 150. The results suggest that myostatin expression is related to regulation of body growth and muscle development, with two different regulatory mechanisms that switch between days 30 and 60. Electronic supplementary material The online version of this article (10.1007/s11033-018-4187-7) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
Externí odkaz: |