Regulation of myostatin expression is associated with growth and muscle development in commercial broiler and DMC muscle

Autor: Sumei Zhao, Xu Zhiqiang, Rong Hua, Dahai Gu, Huang Ying, Changrong Ge, Xiaobo Chen, Li Zhengtian, Wang Kun, Dou Tengfei, Markandeya Jois, Marinus F.W. te Pas, Jia Junjing, Liu Lixian, Jiarong Zhang, Hu Wenyuan, Li Qihua
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Muscle tissue
medicine.medical_specialty
animal structures
Mrna expression
Gene Expression
Myostatin
Biology
Breeding
Muscle Development
Commercial broiler chicken
Muscle hypertrophy
Avian Proteins
03 medical and health sciences
Internal medicine
Genetics
medicine
Animals
RNA
Messenger
Animal Husbandry
Fokkerij & Genomica
Muscle
Skeletal
Molecular Biology
Daweishan mini chicken
Uncategorized
Growth rate
0402 animal and dairy science
Broiler
Skeletal muscle
mRNA expression
04 agricultural and veterinary sciences
General Medicine
musculoskeletal system
040201 dairy & animal science
Breed
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Phenotype
Gene Expression Regulation
Muscle weight
biology.protein
WIAS
Original Article
Chickens
Animal Breeding & Genomics
Zdroj: Molecular Biology Reports, 45(4), 511-522
Molecular Biology Reports
Molecular Biology Reports 45 (2018) 4
ISSN: 0301-4851
Popis: Myostatin is a negative regulator of skeletal muscle growth. Muscle tissue is the largest tissue in the body and influences body growth. Commercial Avian broiler chickens are selected for high growth rate and muscularity. Daweishan mini chickens are a slow growing small-sized chicken breed. We investigated the relations between muscle (breast and leg) myostatin mRNA expression and body and muscle growth. Twenty chickens per breed were slaughtered at 0, 30, 60, 90, 120, and 150 days of age. Body and muscle weights were higher at all times in Avian chickens. Breast muscle myostatin expression was higher in Avian chickens than in Daweishan mini chickens at day 30. Myostatin expression peaked at day 60 in Daweishan mini chickens and expression remained higher in breast muscle. Daweishan mini chickens myostatin expression correlated positively with carcass weight, breast and leg muscle weight from day 0 to 60, and correlated negatively with body weight from day 90 to 150, while myostatin expression in Avian chickens was negatively correlated with carcass and muscle weight from day 90 to 150. The results suggest that myostatin expression is related to regulation of body growth and muscle development, with two different regulatory mechanisms that switch between days 30 and 60. Electronic supplementary material The online version of this article (10.1007/s11033-018-4187-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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