New DRB complexes for new DRB functions in plants
| Autor: | Yerim Kwon, Patrice Dunoyer, Thomas Montavon, Aude Zimmermann, Fabrice Michel |
|---|---|
| Přispěvatelé: | Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA) |
| Rok vydání: | 2017 |
| Předmět: |
Ribonuclease III
0301 basic medicine Small interfering RNA Small RNA Arabidopsis Endogeny Cofactor 03 medical and health sciences [SDV.BV]Life Sciences [q-bio]/Vegetal Biology RNA Small Interfering Point of View Molecular Biology RNA Double-Stranded Genetics biology fungi RNA-Binding Proteins food and beverages RNA Cell Biology Plants biology.organism_classification RNA silencing 030104 developmental biology Multigene Family biology.protein RNA Interference Dicer |
| Zdroj: | RNA Biology RNA Biology, Taylor & Francis, 2017, 14 (12), pp.1637-1641. ⟨10.1080/15476286.2017.1343787⟩ |
| ISSN: | 1555-8584 1547-6286 |
| Popis: | Double-stranded RNA binding (DRB) proteins are generally considered as promoting cofactors of Dicer or Dicer-like (DCL) proteins that ensure efficient and precise production of small RNAs, the sequence-specificity guide of RNA silencing processes in both plants and animals. However, the characterization of a new clade of DRB proteins in Arabidopsis has recently challenged this view by showing that DRBs can also act as potent inhibitors of DCL processing. This is achieved through sequestration of a specific class of small RNA precursors, the endogenous inverted-repeat (endoIR) dsRNAs, thereby selectively preventing production of their associated small RNAs, the endoIR-siRNAs. Here, we concisely summarize the main findings obtained from the characterization of these new DRB proteins and discuss how the existence of such complexes can support a potential, yet still elusive, biological function of plant endoIR-siRNAs. |
| Databáze: | OpenAIRE |
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