The homozygous FcγRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes
| Autor: | Chloé Charroing, Dominique Lasne, Claire Pouplard, Hervé Watier, Charlotte Magdelaine-Beuzelin, Yves Gruel |
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| Rok vydání: | 2004 |
| Předmět: |
Immunology
Platelet Factor 4 Polymorphism Single Nucleotide Biochemistry Immunoglobulin G Gene Frequency Antigens CD Risk Factors Heparin-induced thrombocytopenia Genotype Humans Medicine Platelet Autoantibodies biology Heparin business.industry Homozygote Receptors IgG Cell Biology Hematology medicine.disease Thrombocytopenia Allotype Case-Control Studies biology.protein Antibody business Platelet factor 4 medicine.drug |
| Zdroj: | Blood. 104:2791-2793 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2004-01-0058 |
| Popis: | We hypothesized that Fcγ receptor IIIa (FcγRIIIa), a polymorphic receptor for the Fc portion of immunoglobulin G (IgG) other than FcγRIIa, was involved in heparin-induced thrombocytopenia (HIT). FcγRIIa-131 and FcγRIIIa-158 genotypes were determined in 102 patients with definite HIT and in 2 control groups of patients treated by heparin (86 subjects without detectable antibodies [Abs] to heparin-platelet factor 4 [H/PF4], Ab- group; 84 patients with Abs to H/PF4 without HIT, Ab+ group). There were no significant differences in genotype distribution or allele frequencies between the 3 groups for FcγRIIa-131H/R polymorphism. In contrast, FcγRIIIa-158V homozygotes were more frequent in the HIT group than in the Ab+ group (P = .02), a difference that was more pronounced in patients with high levels of anti-H/PF4 Abs (P = .01). Since anti-H/PF4 Abs are mainly IgG1 and IgG3, clearance of sensitized platelets may be increased in patients homozygous for the FcγRIIIa-158V allotype, thus contributing to the development of thrombocytopenia. (Blood. 2004;104:2791-2793) |
| Databáze: | OpenAIRE |
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