Cancer metabolomic markers in urine: evidence, techniques and recommendations
| Autor: | Annika Hohm, Igor A. Kaltashov, Piet Habbel, Lindsey A. Vandergrift, Johannes Nowak, Sarah S. Dinges, Leo L. Cheng |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Urologic Neoplasms medicine.medical_specialty Urinalysis Urology Urinary system Urine 03 medical and health sciences 0302 clinical medicine Metabolomics Neoplasms Biomarkers Tumor Humans Medicine Intensive care medicine Early Detection of Cancer medicine.diagnostic_test business.industry Liver Neoplasms Prostatic Neoplasms Cancer medicine.disease 030104 developmental biology Neoplasms diagnosis 030220 oncology & carcinogenesis Practice Guidelines as Topic Metabolome Cancer biomarkers business |
| Zdroj: | Nature Reviews Urology. 16:339-362 |
| ISSN: | 1759-4820 1759-4812 |
| Popis: | Urinary tests have been used as noninvasive, cost-effective tools for screening, diagnosis and monitoring of diseases since ancient times. As we progress through the 21st century, modern analytical platforms have enabled effective measurement of metabolites, with promising results for both a deeper understanding of cancer pathophysiology and, ultimately, clinical translation. The first study to measure metabolomic urinary cancer biomarkers using NMR and mass spectrometry (MS) was published in 2006 and, since then, these techniques have been used to detect cancers of the urological system (kidney, prostate and bladder) and nonurological tumours including those of the breast, ovary, lung, liver, gastrointestinal tract, pancreas, bone and blood. This growing field warrants an assessment of the current status of research developments and recommendations to help systematize future research. Urinalysis has long been used as a tool for managing diseases, but 21st century techniques have enabled measurement of metabolomic urinary cancer biomarkers using NMR and mass spectrometry. In this Review, the authors discuss the current status of research developments and offer recommendations to help systematize future research in the field. |
| Databáze: | OpenAIRE |
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