An Expert Panel Statement on the Beneficial Effects of Human Milk Oligosaccharides (HMOs) in Early Life and Potential Utility of HMO-Supplemented Infant Formula in Cow's Milk Protein Allergy
| Autor: | Fügen Çullu Çokuğraş, Zeynep Tamay, Haluk Cokugras, Aydan Kansu, Gülbin Bingöl, Hasan Özen, Bulent Enis Sekerel |
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| Přispěvatelé: | Acibadem University Dspace |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Diarrhea Allergy immune tolerance Breast-Milk Review Growth Gut flora Immune tolerance Immune system Intestinal mucosa intestinal mucosal barrier Mechanisms Immunology and Allergy Medicine cow's milk protein allergy health care economics and organizations Protection biology gut microbiota business.industry Reveals infant formula Intestinal mucosal barrier biology.organism_classification medicine.disease Food Allergy 2'-Fucosyllactose Infant formula Cow's milk protein Immunology human milk oligosaccharides Cell business cow’s milk protein allergy |
| Zdroj: | Journal of Asthma and Allergy |
| DOI: | 10.2147/JAA.S323734 |
| Popis: | This review by pediatric gastroenterology and allergy-immunology experts aimed to address the biological roles of human milk oligosaccharides (HMOs) and the potential utility of HMOs in prevention of allergy with particular emphasis on cow's milk protein allergy (CMPA). The participating experts consider HMOs amongst the most critical bioactive components of human milk, which act as antimicrobials and antivirals by preventing pathogen adhesion to epithelial cells, as intestinal epithelial cell modulators by enhancing maturation of intestinal mucosa and intestinal epithelial barrier function, as prebiotics by promoting healthy microbiota composition and as immunomodulators by modulating immune cells indirectly and directly. Accordingly, the participating experts consider the proposed link between HMOs and prevention of allergy to be primarily based on the impact of HMO on gut microbiota, intestinal mucosal barrier, immunomodulation and immune maturation. Along with the lower risk of respiratory and gastrointestinal infections, HMO supplemented formulas seem to be promising alternatives in the management of CMPA. Nonetheless, the effects of individual as well as complex mixtures of HMO in terms of clear clinical and immunological effects and tolerance development need to be further explored to fully realize the immunomodulatory mechanisms and the potential for HMOs in prevention of allergic diseases and CMPA. Abbott Nutrition Turkey The authors would like to thank Cagla Ayhan, MD and Prof. Sule Oktay, MD, PhD from KAPPA Consultancy Training Research Ltd, Istanbul who provided editorial support funded by Abbott Nutrition Turkey. |
| Databáze: | OpenAIRE |
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