Chronic effects of maternal smoking on pulse waves in the fetal aorta
| Autor: | Jie Hu, Gerhard Gennser, Nina B. Kyrklund-Blomberg |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood Pressure Gestational Age Ultrasonography Prenatal Pregnancy medicine.artery Internal medicine medicine Thoracic aorta Humans Prospective Studies Systole Cotinine Pulse wave velocity Aorta Fetus business.industry Smoking Obstetrics and Gynecology Gestational age medicine.disease Case-Control Studies Pulsatile Flow Pediatrics Perinatology and Child Health Cardiology Arterial stiffness Regression Analysis Aortic stiffness Female business Blood Flow Velocity |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 19(8) |
| ISSN: | 1476-7058 |
| Popis: | In order to evaluate the impact of maternal smoking on arterial stiffness in utero, pulse wave characteristics in the fetal aorta were investigated. A prospective clinical study was made of 34 smoking and 34 non-smoking healthy volunteers with uncomplicated pregnancies at 31-40 weeks of gestation.The mechanical properties of the fetal thoracic aorta were assessed by an ultrasonic phase-locking echo-tracking system. For each fetus with a smoking mother, a non-smoking control matched for gestational and maternal age was monitored. Women with later appearing pregnancy complications were excluded. Pulse wave velocity (PWV), maximum diameter in systole (Ds), end-diastolic diameter (Dd), pulse amplitude (DeltaD), and maximum incremental velocity (MIV) in the fetal aorta were measured and analyzed in relation to maternal smoking and gestational age.Results were computed on fetuses of 32 smokers and 30 non-smokers. PWV increased with gestational age in smokers (corr. coeff. 0.49, p0.006) but not in non-smokers (corr. coeff. -0.12). MIV did not change in smokers (corr. coeff. -0.15) but increased in non-smokers (corr. coeff. 0.40, p0.03). Differences in regression lines between the groups regarding PWV and MIV were significant (p0.02 for both).Maternal smoking seems to promote the stiffening of the fetal aorta during gestation. |
| Databáze: | OpenAIRE |
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