Impact of serological and PCR testing requirements on the selection of COVID ‐19 convalescent plasma donors
| Autor: | Alex T Freedenberg, Margaret E Shevik, Tahmeena Ahmed, Nicholas J Browne, Giuseppina A Caravella, Elliott Bennett-Guerrero, Laura M Generale, Megan E. Cosgrove, Jason A. Carter, Linda J Mamone, Lillian R Talbot, Molly G Rago, Jamie L. Romeiser |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) media_common.quotation_subject Immunology immunology (other than RBC serology) Blood Donors 030204 cardiovascular system & hematology Immunoglobulin G law.invention Serology COVID-19 Serological Testing Donor Selection blood component preparations 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Immunology and Allergy Prospective cohort study donors media_common Original Research biology Donor selection business.industry Reverse Transcriptase Polymerase Chain Reaction Convalescence COVID-19 Hematology Middle Aged COVID-19 Nucleic Acid Testing biology.protein Female Antibody business 030215 immunology |
| Zdroj: | Transfusion |
| ISSN: | 1537-2995 0041-1132 |
| DOI: | 10.1111/trf.16293 |
| Popis: | Background Convalescent plasma is undergoing randomized trials as a potential therapeutic option for COVID‐19 infection. Little empirical evidence exists regarding the determination of donor eligibility and experiences with donor selection. Study Design and Methods This prospective study was conducted at a tertiary care hospital in New York to select plasma donors for a randomized, double‐blind, controlled convalescent plasma trial. Clearance for donation required successful completion of an online questionnaire and an in‐person screening visit, which included (a) completion of a Donor Health Questionnaire (DHQ), (b) Immunoglobulin G (IgG) antibody testing using an immunochromatographic anti‐ severe acute respiratory coronavirus 2 (SARS‐CoV‐2) test, (c) Polymerase chain reaction (PCR) testing if |
| Databáze: | OpenAIRE |
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