Enhanced pharmacokinetics of omeprazole when formulated as gastroretentive microspheres along with piperine
| Autor: | Bindu Madhavi Boddupalli, Ramalingam Ramani, Ravinder Nath Anisetti, Nagulu Malothu |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
lcsh:Arctic medicine. Tropical medicine Bioavailability Chemistry lcsh:RC955-962 Piperine Gastroretentive microspheres lcsh:R lcsh:Medicine Absorption (skin) Pharmacology Microsphere chemistry.chemical_compound Infectious Diseases Pharmacokinetics Area under curve medicine Omeprazole medicine.drug |
| Zdroj: | Asian Pacific Journal of Tropical Disease, Vol 4, Iss Sup 1, Pp 129-133 (2014) |
| ISSN: | 2222-1808 |
| Popis: | Objective To investigate the formulation of gastroretentive microspheres of omeprazole along with piperine and estimate the pharmacokinetic parameters in comparison with omeprazole alone. Methods In our present investigation, gastroretentive microspheres of omeprazole were prepared with the inclusion of piperine. Pharmacokinetic parameters like C max , T max and area under curve were estimated by administering the prepared microspheres to rabbits and the results were compared with omeprazole alone. Results There was a significant increase in area under curve from 3.441±1.093 mg·h/mL to 14.422±0.708 mg·h/mL along with an increase in C max . Conclusions This clearly shows the increased absorption and decreased metabolism of omeprazole when administered along with piperine as gastroretentive microspheres. |
| Databáze: | OpenAIRE |
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