Satellite DNA evolution: old ideas, new approaches
| Autor: | Andrew G. Clark, Michael P McGurk, Daniel A. Barbash, Sarah Sander Lower |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genome Reproductive Isolation Base Sequence Satellite DNA Eukaryota Reproductive isolation DNA Satellite Biology Article Evolution Molecular 03 medical and health sciences Multicellular organism 030104 developmental biology Chromosome (genetic algorithm) Evolutionary biology Chromosome Segregation Genetics Animals Satellite Identification (biology) Repeated sequence Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development. 49:70-78 |
| ISSN: | 0959-437X |
| Popis: | A substantial portion of the genomes of most multicellular eukaryotes consists of large arrays of tandemly repeated sequence, collectively called satellite DNA. The processes generating and maintaining different satellite DNA abundances across lineages are important to understand as satellites have been linked to chromosome mis-segregation, disease phenotypes, and reproductive isolation between species. While much theory has been developed to describe satellite evolution, empirical tests of these models have fallen short because of the challenges in assessing satellite repeat regions of the genome. Advances in computational tools and sequencing technologies now enable identification and quantification of satellite sequences genome-wide. Here, we describe some of these tools and how their applications are furthering our knowledge of satellite evolution and function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect