Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell
| Autor: | Novikov Dv, N V Krasnogorova, Alexander Karaulov, V. V. Novikov, S G Selivanova, E N Gorshkova, S. N. Pleskova |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Gene Expression Protein Corona Apoptosis Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Quantum Dots Autophagy Cadmium Compounds Humans Selenium Compounds Inflammation Messenger RNA Chemistry General Medicine Molecular biology 030104 developmental biology Zinc Compounds Leukocytes Mononuclear Cytokines Tumor necrosis factor alpha Inflammation Mediators Cell activation Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 169(1) |
| ISSN: | 1573-8221 |
| Popis: | We studied changes in the transcription of genes encoding cytokines (TNF, IL-6, IL-10, and IL-32), cell activation markers (ICAM1, CD38, Fas, and FCGRIII), ROS production catalyst (NOX2), autophagy (Beclin 1, LC3B, and p62) and apoptosis (BAX, BCL2) regulators in peripheral blood mononuclear cells upon contact with quantum dots CdSe/ZnS-MPA and CdSe/CdSeZnS/ZnS-PTVP. Up-regulation of TNF, ICAM1, Fas, p62 mRNA and down-regulation of the FCGRIII and NOX2 mRNA in response to the presence of quantum dots were revealed. The formation of serum protein corona on the surface of quantum dots abolished this effect. |
| Databáze: | OpenAIRE |
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