Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging
| Autor: | Hervé Pageon, Hélène Zucchi, Zhenyu Dai, David R. Sell, Christopher M. Strauch, Vincent M. Monnier, Daniel Asselineau |
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| Rok vydání: | 2015 |
| Předmět: |
MMP3
extracellular matrix lcsh:Medicine Bioinformatics General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Dermis oxoaldehydes Glycation Laminin methylglyoxal medicine Original Research Article glucose Pentosidine lcsh:QH301-705.5 biology lcsh:R aging Methylglyoxal Molecular biology Procollagen peptidase medicine.anatomical_structure lcsh:Biology (General) chemistry glycation biology.protein Keratinocyte growth factor |
| Zdroj: | BioResearch Open Access BioResearch Open Access, Vol 4, Iss 1, Pp 54-64 (2015) |
| ISSN: | 2164-7860 |
| Popis: | Advanced glycation end products (AGEs) accumulate in the aging skin. To understand the biological effects of individual AGEs, skin reconstructed with collagen selectively enriched with Nɛ-(carboxymethyl)-lysine (CML), Nɛ-(carboxyethyl)-lysine (CEL), methylglyoxal hydroimidazolone (MG-H1), or pentosidine was studied. Immunohistochemistry revealed increased expression of α6 integrin at the dermal epidermal junction by CEL and CML (p |
| Databáze: | OpenAIRE |
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