The Impact of Acamprosate on Cue Reactivity in Alcohol Dependent Individuals
| Autor: | Jens M. Langosch, Hans M. Olbrich, Jürgen Hennig, Bernd Feige, Kai Spiegelhalder, Kolja Jahnke, Wolfram Regen, Andrea Kiemen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Taurine Brain activity and meditation Acamprosate Placebo Gyrus Cinguli Retrosplenial cortex Cortex (anatomy) medicine Humans Single-Blind Method Pharmacology (medical) medicine.diagnostic_test business.industry Brain Middle Aged Magnetic Resonance Imaging Alcoholism Psychiatry and Mental health medicine.anatomical_structure Cue reactivity Anesthesia Posterior cingulate Female Cues business Functional magnetic resonance imaging Alcohol Deterrents medicine.drug |
| Zdroj: | Journal of Clinical Psychopharmacology. 32:661-665 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/jcp.0b013e318267b586 |
| Popis: | Alcohol cue-induced brain activation has been studied extensively in alcoholics. However, little is known about the impact of standard treatment protocols on this phenomenon. The current study aimed at investigating the impact of the anticraving substance acamprosate on alcohol cue-related brain activity. Patients underwent a functional magnetic resonance imaging investigation before the beginning of medication with acamprosate or placebo (T0) and 2 weeks later (T1). All patients also received psychiatric inpatient treatment including psychotherapeutic interventions. Twenty-nine patients were included in the T0 analysis and 22 patients in the T1 analysis. At T0, a cluster in the left and right posterior cingulate cortex, covering parts of the retrosplenial cortex, was significantly associated with alcohol versus neutral cue exposure. At T1, no significant cluster was found for the alcohol-versus-neutral contrast. The analysis of the impact of acamprosate on cue-related activity in the posterior cingulate cortex cluster revealed no significant difference to placebo. These results provide further evidence for the involvement of the posterior cingulate cortex in alcohol cue exposure. However, in comparison with psychiatric inpatient treatment alone, there was no additional effect of acamprosate on cue-related brain activity. |
| Databáze: | OpenAIRE |
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