Phosphorus(V) corrole: DNA binding, photonuclease activity and cytotoxicity toward tumor cells
| Autor: | Hui Wang, Hai-Yang Liu, Yi-Guang Wang, Zhao Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Porphyrins
Cell Survival chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor Drug Discovery Animals Humans Structure–activity relationship Binding site Corrole Cytotoxicity Molecular Biology Binding Sites Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Phosphorus Organic Chemistry DNA Photochemical Processes 0104 chemical sciences chemistry Toxicity Agarose gel electrophoresis Cattle |
| Zdroj: | Bioorganic Chemistry. 67:57-63 |
| ISSN: | 0045-2068 |
| Popis: | A new phosphorus(V) corrole, 10-(4-hydroxylphenyl)-5,15-bis(pentafluorophenyl)corrolato (trans-dihydroxo)phosphorus(V) 1-P, was synthesized and characterized. The interaction of 1-P with calf thymus DNA (CT-DNA) was studied by multi-spectroscopic methods. The photonuclease activity of this complex was examined by agarose gel electrophoresis. 1-P may bind to CT-DNA via an outside binding mode and display good photonuclease activity. 1-P displayed low dark toxicity but high photocytotoxic activity against H460 and A549 tumor cell lines. |
| Databáze: | OpenAIRE |
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