Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins
| Autor: | M. R. Malinow, Joe C. Christian, Terry Reed, B. Upson |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Adult male Intraclass correlation Dizygotic twin Monozygotic twin Biology chemistry.chemical_compound Risk Factors Internal medicine Blood plasma Twins Dizygotic Genetics medicine Humans Longitudinal Studies Genetics (clinical) Aged Veterans Genetic Variation Twins Monozygotic Middle Aged Heritability Homocyst(e)ine Endocrinology chemistry Cardiovascular Diseases |
| Zdroj: | Clinical Genetics. 39:425-428 |
| ISSN: | 1399-0004 0009-9163 |
| DOI: | 10.1111/j.1399-0004.1991.tb03053.x |
| Popis: | Plasma homocyst(e)ine level was determined for 96 identical (MZ) and 92 fraternal (DZ) adult male twins aged 59-69. There was no difference in mean between MZ (10.31 nmol/ml) and DZ (10.36 nmol/ml) twins. The intraclass correlation coefficient of the log-transformed homocyst(e)ine level in 43 complete MZ and 39 complete DZ pairs was 0.55 and 0.19, respectively. The MZ correlation was significantly (p less than 0.05) greater than the DZ correlation, suggesting that the level of plasma homocyst(e)ine is genetically influenced. |
| Databáze: | OpenAIRE |
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