Automated synthesis of (R) ‐[ 18 F]MH.MZ on the iPhase Flexlab reaction platform

Autor:	Adam J. Rosenberg, Yiu‐Yin Cheung, Fei Liu, Todd E. Peterson, James Silverman, Ciaran M. Considine, Daniel O. Claassen
Rok vydání:	2022
Předmět:	Fluorine Radioisotopes Radiochemistry Positron-Emission Tomography Organic Chemistry Drug Discovery Radiology Nuclear Medicine and imaging Radiopharmaceuticals Biochemistry Article Spectroscopy Analytical Chemistry
Zdroj:	J Labelled Comp Radiopharm
ISSN:	1099-1344 0362-4803
DOI:	10.1002/jlcr.3975
Popis:	(R)-[(18)F]MH.MZ ([(18)F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT(2A) receptor. To facilitate clinical trials a fully automated radiosynthesis procedure for [(18)F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 minutes with a radiochemical yield of 7 ± 0.9% (n=3). The radiochemical purity was greater than 99% for [(18)F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n=3). The protocol described herein reliably provides [(18)F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceutical.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52aaf7733a13317653769004f07c086 https://doi.org/10.1002/jlcr.3975 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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