Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media

Autor:	Helene Marie-France Viart, T. S. Larsen, Chiara Tassone, Mads Hartvig Clausen, Thomas Lars Andresen
Rok vydání:	2014
Předmět:	Liposome Propylamines Metals and Alloys General Chemistry Conjugated system Catalysis Coupling reaction Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Matrix-assisted laser desorption/ionization Ether lipid chemistry Pargyline Cyclization Isothiocyanates Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Isothiocyanate Propargyl Materials Chemistry Ceramics and Composites Organic chemistry Thiazolidines POPC Chromatography High Pressure Liquid
Zdroj:	Chemical communications (Cambridge, England). 50(58)
ISSN:	1364-548X
Popis:	A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52aabb894cdb81deaade8652e1921e7 https://pubmed.ncbi.nlm.nih.gov/24903342 Zobrazit plný text záznamu