Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19
| Autor: | Yi Ch, J D Brook, Slingsby T, Packham Ea, McClure P, Lindsay Armstrong-Buisseret, Terrett Ja, Ellington K, Li Qy |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Brachyury Subfamily TBX6 Molecular Sequence Data Eomesodermin Biology Xenopus Proteins Mice Genetics Gene family Animals Humans Amino Acid Sequence Promoter Regions Genetic Phylogeny Expressed Sequence Tags Homeodomain Proteins Chromosome Mapping Zebrafish Proteins Paraxial mesoderm formation DNA-Binding Proteins Chromosomes Human Pair 1 Multigene Family Mesoderm formation biology.protein Chromosomes Human Pair 6 TBR1 Chromosomes Human Pair 3 T-Box Domain Proteins Sequence Alignment Chromosomes Human Pair 16 Transcription Factors |
| Zdroj: | Genomics. 55(1) |
| ISSN: | 0888-7543 |
| Popis: | Brachyury ( T ) is a mouse mutation, first described over 70 years ago, that causes defects in mesoderm formation. Recently several related genes, the T-box gene family, that encode a similar N-terminal DNA binding domain, the T-box, and that play critical roles in human embryonic development have been identified. It has been shown that human TBX5 and TBX3, if mutated, cause developmental disorders, Holt–Oram syndrome (OMIM 142900) and ulnar-mammary syndrome (OMIM 181450), respectively. We have identified four new human members of the T-box gene family, EOMES, TBX6, TBX18, and TBX19, and these genes have been mapped to different chromosomal regions by radiation hybrid mapping. The four T-box genes were classified into four different subfamilies and have also been subjected to phylogenomic analysis. Human EOMES maps at 3p21.3–p21.2. This Tbr1 -subfamily gene is likely to play a significant role in early embryogenesis similar to that described for Xenopus eomesodermin. Human TBX6 maps at 16p12–q12. This Tbx6 -subfamily gene is likely to participate in paraxial mesoderm formation and somitogenesis in human embryo. TBX18 is a novel member of the Tbx1 subfamily that maps at 6q14–q15. Two subgroups, TBX1/10 and TBX15/18 subgroups, could be distinguished within the Tbx1 subfamily. TBX19 is an orthologue of chick TbxT and maps at 1q23–q24. The genomic organization of TBX19 is highly similar to that of human T ( Brachyury ), another human member of the same subfamily. |
| Databáze: | OpenAIRE |
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