Broad autism spectrum and obsessive–compulsive symptoms in adults with the fragile X premutation
Autor: | Susan M. Rivera, Emilio Ferrer, Andrea Schneider, David R Hessl, Stephanie M. Sansone, Flora Tassone, Randi J Hagerman, Cindy Johnston |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male 0301 basic medicine Obsessive-Compulsive Disorder medicine.medical_specialty Autism Spectrum Disorder Neuropsychological Tests Article Fragile X Mental Retardation Protein Young Adult 03 medical and health sciences 0302 clinical medicine Arts and Humanities (miscellaneous) Social cognition Developmental and Educational Psychology medicine Humans Young adult Social Behavior Psychiatry Neurologic Examination medicine.disease FMR1 Fragile X syndrome Psychiatry and Mental health Clinical Psychology 030104 developmental biology Neuropsychology and Physiological Psychology Autism spectrum disorder Fragile X Syndrome Autism Female Psychology Photic Stimulation 030217 neurology & neurosurgery Psychopathology Executive dysfunction |
Zdroj: | The Clinical Neuropsychologist. 30:929-943 |
ISSN: | 1744-4144 1385-4046 |
Popis: | Objective: Clinical observations and a limited number of research studies provide evidence that the fragile X premutation may confer risk for autism, executive dysfunction, and psychopathology. The link to autism spectrum symptoms and social cognition deficits with the premutation remains uncertain, and thus was the focus of the present investigation. Method: Our sample included 131 individuals, 42 men/22 women with the FMR1 premutation (mean age = 31.83 ± 8.59 years) with a normal neurological exam, and 48 men/19 women healthy age-matched controls (mean age = 29.48 ± 7.29 years). Individuals completed a comprehensive neuropsychological battery with additional assessments for social cognition, broad autism spectrum, and obsessive–compulsive (OC) symptoms. Results: Premutation carriers self-reported higher rates of autism-related symptoms (Autism Quotient; p = .001). Among males only, premutation carriers showed more atypical social interaction (p p = .014) during standardized clinical examination on the Autism Diagnostic Observation Schedule (ADOS) relative to controls. Female premutation carriers reported significantly higher rates of OC symptoms compared to control females (p = .012). Molecular measures defining the expanded premutation (FMR1 CGG repeat length and/or mRNA) were significantly associated with a measure of theory of mind (Reading the Mind in the Eyes Task). Conclusions: The results of this study indicate a higher rate of broad autism spectrum symptoms in some males with the premutation and provide evidence for an obsessive–compulsive subtype in female premutation carriers. |
Databáze: | OpenAIRE |
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