KRAS polymorphisms are associated with survival of CRC in Chinese population
| Autor: | Tie Jun Zhou, Hui Lian Wei, Zhi-Hui Yang, Qiong Dai, Juan Huang, Li Chai |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Colorectal cancer Kaplan-Meier Estimate Adenocarcinoma medicine.disease_cause Bioinformatics Polymorphism Single Nucleotide Disease-Free Survival Proto-Oncogene Proteins p21(ras) 03 medical and health sciences Gene Frequency Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele neoplasms Genotyping Genetic Association Studies Survival analysis Aged Proportional Hazards Models business.industry Proportional hazards model General Medicine Middle Aged medicine.disease digestive system diseases Oxaliplatin 030104 developmental biology Chemotherapy Adjuvant Case-Control Studies Female KRAS Colorectal Neoplasms business medicine.drug |
| Zdroj: | Tumor Biology. 37:4727-4734 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1007/s13277-015-4314-1 |
| Popis: | rs12245, rs12587, rs9266, rs1137282, rs61764370, and rs712 of KRAS oncogene are characterized in the 3'UTR. The study highlights the important role of these polymorphisms playing in the susceptibility, oxaliplatin-based chemotherapy sensitivity, progression, and prognosis of CRC. Improved multiplex ligation detection reaction (iMLDR) technique is used for genotyping. An unconditional logistic regression model was used to estimate the association of certain polymorphism and CRC risk. The Kaplan-Meier method, log-rank test, and Cox regression model were used to evaluate the effects of polymorphisms on survival analysis. Results demonstrated that TT genotype and T allele of rs712 were associated with the increased risk of CRC; the patients with GG genotype and G allele of rs61764370 had a shorter survival and a higher risk of relapse or metastasis of CRC. Our studies supported the conclusions that rs61764370 and rs712 polymorphisms of the KRAS are functional and it may play an important role in the development of CRC and oxaliplatin-based chemotherapy efficiency and prognosis of CRC. |
| Databáze: | OpenAIRE |
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