Identification of Serologic Markers for School-Aged Children With Congenital Rubella Syndrome
| Autor: | Terri B, Hyde, Helena Keico, Sato, LiJuan, Hao, Brendan, Flannery, Qi, Zheng, Kathleen, Wannemuehler, Flávia Helena, Ciccone, Heloisa, de Sousa Marques, Lily Yin, Weckx, Marco Aurélio, Sáfadi, Eliane, de Oliveira Moraes, Marisa Mussi, Pinhata, Jaime, Olbrich Neto, Maria Cecilia, Bevilacqua, Alfredo, Tabith Junior, Tatiana Alves, Monteiro, Cristina Adelaide, Figueiredo, Jon K, Andrus, Susan E, Reef, Cristiana M, Toscano, Carlos, Castillo-Solorzano, Joseph P, Icenogle, Sueli Pires, Curti |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Adolescent Rubella Syndrome Congenital Antibody Affinity Antibodies Viral medicine.disease_cause Rubella Measles Article Serology otorhinolaryngologic diseases medicine Humans Immunology and Allergy Avidity Child Students Congenital rubella syndrome Schools business.industry Transmission (medicine) Rubella virus medicine.disease Vaccination Infectious Diseases Immunoglobulin G Immunology Female business Biomarkers |
| Zdroj: | Journal of Infectious Diseases. 212:57-66 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiu604 |
| Popis: | Rubella virus (RUBV) infection during pregnancy can lead to fetal infection and cause miscarriage, fetal death, or congenital rubella syndrome (CRS), which includes birth defects such as cataracts, sensorineural hearing loss, heart defects, and mental retardation [1]. Despite availability of safe, effective, and inexpensive vaccines, the World Health Organization (WHO) estimated that 103 000 infants with CRS were born in 2010, mainly in developing countries that have not introduced rubella vaccination [1]. In 1998, the Technical Advisory Group on Vaccine-Preventable Diseases of the Region of the Americas recommended that all countries in the region incorporate rubella virus (RUBV)–containing vaccine (RCV) into their childhood vaccination program [2, 3]. In 2011, the WHO recommended that all countries take the opportunity offered by accelerated measles control and elimination activities to introduce RCV [4]. By 2012, 132 (68%) of 194 WHO Member States included RCV in their routine immunization programs [5]. Determining the burden of CRS-related disabilities may inform decisions regarding vaccine introduction. The CRS incidence has been measured in follow-up studies of women infected with RUBV during pregnancy [6, 7], obtained through CRS surveillance targeting children 133 confirmed rubella cases in pregnant women were reported in 1999 and 2000 [23]. Brazil developed a vaccination effort, using measles-rubella vaccine (containing Edmonston-Zagreb measles and RA 27/3 RUBV strains), to accelerate CRS prevention during 2000 and 2001. A second national rubella vaccination campaign, conducted in 2008, interrupted endemic rubella transmission; the last endemic CRS case occurred in 2009. The goal of the current serologic study was to characterize the immune responses of school-aged children with CRS and compare these responses with those of their biological mothers and a group of similarly aged children without CRS. We hypothesized that specific immune responses, including the persistence of low-avidity IgG antibody, the level of the IgG anti-E1 signal, and the level of the IgG anti-C signal, would be associated with CRS. |
| Databáze: | OpenAIRE |
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